HEALTHY GENOME
- Intact DNA
- Normal Chromatin
- Healthy Mitochondria
- Stable Genome
OXIDATIVE DNA INJURY
- Oxidative DNA Damage
- DNA Fragmentation
- Chromatin Injury
- Damaged Mitochondria
- Genomic Instability
OXIPASSIVE®
In Men's Reproductive Health
Sperm DNA Integrity & Oxidative DNA Damage
Restoring Redox Homeostasis in the Testicular Microenvironment.
Sperm Function
DNA Integrity
Oxidative Stress
Healthy DNA
Intact Chromatin
ROS Attack
Free Radical Burst
DNA Oxidation
Base Modification
DNA Strand Breaks
SSB & DSB Events
DNA Fragmentation
Chromatin Instability
Reduced Reproductive
Potential
HEALTHY GENOME vs OXIDATIVE DNA INJURYHEALTHY GENOME vs OXIDATIVE DNA INJURY
EXECUTIVE CLINICAL SNAPSHOTEXECUTIVE CLINICAL SNAPSHOT
Clinical Concept
- Elevated sperm DNA fragmentation represents an advanced biological consequence of persistent oxidative stress.
- Functional impairment may exist despite apparently acceptable conventional semen parameters.
- Routine semen analysis provides limited information regarding genomic integrity.
Identify the Right Patient ProfileIdentify the Right Patient Profile
Patient SelectionPatient Selection
Consider adjunctive redox support for patients presenting with the following clinical indicators.
Repeated ART Failure
Recurrent Pregnancy Loss
Persistent Unexplained Infertility
Recurrent Abnormal Semen Analysis
Multiple Oxidative Stress Risk Factors
CONSIDER DNA FRAGMENTATION TESTING
Why Oxidative DNA Damage MattersWhy Oxidative DNA Damage Matters
Disease BiologyDisease Biology
Persistent Oxidative Stress
DNA Oxidation
DNA Fragmentation
Genomic Instability
Reduced Fertility Potential
Platform Highlights: Why Oxipassive®?Platform Highlights: Why Oxipassive®?
Ingredient Platform
N-Acetyl-L-Cysteine 300 mg
Supports endogenous glutathione biosynthesis
Glycine 300 mg
Supports creatine & glutathione biosynthesis
OXIPASSIVE® Dual-Precursor Strategy
Supporting endogenous glutathione-dependent defense system. Maintaining genomic integrity through restoration of redox homeostasis.
Evidence Highlight
Why Glycine?
- Lead Toxicity Model
- Oxidative Stress
- Mitochondrial Impairment
- Impaired Sperm Kinematics
- Protective Role of Glycine
Why NAC?
- NAC & Chromatin
- NAC & Semen Parameters
- NAC & Human Sperm
Clinical Evidence DashboardClinical Evidence Dashboard
Clinical Utility
- DNA Fragmentation Testing
- Clinical Decision Support
- Oxidative Stress Assessment
Human Evidence
- Effects of N-acetyl-cysteine supplementation on sperm quality, chromatin integrity and oxidative stress
- Effects of N-acetylcysteine on semen parameters
Visual Summary
Oxidative stress
DNA damage
OXIPASSIVE® Dual-Precursor Support
Improved Genomic Stability
Clinical Positioning
Elevated sperm DNA fragmentation represents an important functional manifestation of oxidative stress-associated sperm dysfunction.
Mechanism-oriented antioxidant strategies are intended to support physiological intracellular defense systems while preserving genomic integrity.
Scientific References
GSH Functionality
DNA Fragmentation Review
DNA Fragmentation Review
Glutathione Biology
GlyNAC Biology
Glutathione Metabolism
Glutathione Synthesis
N-ACETYL-L-CYSTEINE
NAC & Chromatin Integrity - R Jannatifar · 2019
NAC & Semen Parameters
NAC Safety Review
NAC & Human Sperm
Glycine
Glycine & Lead Toxicity
Reviews
Oxidative Stress & Male Infertility Review
Glutathione & Infertility Review