OXIPASSIVE®

Reward Circuit Dysregulation in Addiction-Related Craving

Modulate Glutamatergic Dysregulation
Support Recovery-Related Neuroplasticity
Promote Reward Circuit Resilience

Brain illustration showing the neural pathways of the reward circuit

Disease Biology

Healthy Reward Circuit
Repeated Substance Exposure
Glutamatergic Dysregulation
Oxidative Neurobiological Stress

Reduced Endogenous Glutathione
Reward Circuit Dysfunction
Persistent Addiction-Related Craving
Increased Relapse Vulnerability

Healthy Reward Circuit
Repeated Substance Exposure
Glutamatergic Dysregulation
Oxidative Neurobiological Stress

Reduced Endogenous Glutathione
Reward Circuit Dysfunction
Persistent Addiction-Related Craving
Increased Relapse Vulnerability

Patient Profile

Oxipassive Patient Profile

Persistent craving despite ongoing treatment
Cue-induced craving
High relapse vulnerability
Chronic substance-related neurobiological stress
Ongoing compulsive drug-seeking behaviour
Persistent neurochemical instability during recovery

Typical Clinical Settings

Nicotine Use Disorder
Cocaine Use Disorder
Cannabis Use Disorder
Alcohol Use Disorder
Amphetamine-related Disorders
Other Substance Use Disorders

Oxipassive Patient Profile

Persistent craving despite ongoing treatment
Cue-induced craving
High relapse vulnerability
Chronic substance-related neurobiological stress
Ongoing compulsive drug-seeking behaviour
Persistent neurochemical instability during recovery

Typical Clinical Settings

Nicotine Use Disorder
Cocaine Use Disorder
Cannabis Use Disorder
Alcohol Use Disorder
Amphetamine-related Disorders
Other Substance Use Disorders

Neuro-Redox Intervention In Reward Circuit Dysfunction

N-Acetyl L-Cysteine (NAC)

Restores extracellular glutamate homeostasis
Supports physiological glutamatergic signaling
Reduces pathological cue-induced glutamate dysregulation
Supports Reward Circuit Recovery

Glycine

Supports physiological NMDA receptor signaling
Supports adaptive reward learning
Supports recovery-related neuroplasticity
Contributes to Endogenous Glutathione Synthesis
Supports neuronal resilience during recovery

Disease-Specific Biological Intervention Flow

Reward Circuit
Pathological Glutamate Dysregulation
Persistent Addiction-Related Craving
OXIPASSIVE (NAC + Glycine)
Adaptive Reward Learning
Improved Neuroplastic Recovery
Reduced Biological Vulnerability to Relapse

Reward Circuit
Pathological Glutamate Dysregulation
Persistent Addiction-Related Craving
OXIPASSIVE (NAC + Glycine)
Adaptive Reward Learning
Improved Neuroplastic Recovery
Reduced Biological Vulnerability to Relapse

Clinical Positioning

Primary Biological Targets

Glutamate Homeostasis
Endogenous Glutathione
Neuro-Redox Balance
Neuronal Resilience

Clinical Objectives

Restore Glutamate homeostasis
Reduce sub-clinical glutamate dysregulation
Reduce oxidative neurobiological stress
Support adaptive reward learning
Enhance neuroplastic recovery
Support Glutathione-Dependent Cellular Redox Regulation
Support Synaptic Homeostasis During Recovery
Reduce relapse vulnerability
Support long-term neurochemical stability during recovery

Key Scientific References

Frontiers in Pharmacology (2024)

Dual antioxidant mechanismsPMCID: PMC11412889

Clin Psychopharmacol & Neuroscience (2021)

Meta-analysis psychiatric outcomesPMCID: PMC8077050

American Journal on Addictions (2017)

NAC for craving systematic reviewPMID: 28898494

Addiction Biology (2024)

Adjunctive support pathwaysPMID: 39556483

Tomko et al. (2018)

GSH synthesis optimizationPMCID: PMC5993450

Prisciandaro JJ et al. (2019)

Reward circuit CNS targetsPMCID: PMC6621545

Kalivas (2009)

The glutamate homeostasis hypothesis of addictionPMID: 19571793